Concentration Ratios of Codeine-to-Morphine in Plasma after a Single Oral Dose (100 mg) of Codeine Phosphate
نویسندگان
چکیده
منابع مشابه
Correlation of saliva codeine concentrations with plasma concentrations after oral codeine administration.
A clinical study was designed to determine if there was a predictable relationship between saliva and plasma codeine concentrations. Drug-free volunteers (n = 17) were administered a 30-mg dose of liquid codeine phosphate. Plasma and saliva specimens were collected at various times for 24 h after administration. Plasma and saliva were analyzed for codeine and morphine by positive-ion chemical i...
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BACKGROUND Both the illicit drug heroin and the prescription drug codeine are metabolized to morphine, which tends to complicate interpretation of opiate-positive samples. We report here the concentrations of morphine and codeine, the morphine/codeine ratios, and 6-acetylmorphine (6-AM) in blood specimens from individuals arrested for driving under the influence of drugs (DUID) in Sweden. The r...
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This report describes a case of accidental intravenous administration of codeine phosphate (1 mg.kg-1) to a previously healthy five-year-old boy, who was undergoing strabismus surgery. Hypoxaemia (SpO2 85% with FIO2 of 1) and hypotension (systolic BP 65 mmHg) resulted, which responded to resuscitation with lactated Ringers' (20 ml.kg-1) and phenylephrine (2 micrograms.kg-1). The degree of hypox...
متن کاملCodeine phosphate in paediatric medicine.
Codeine is an old drug that still enjoys widespread clinical use although the logical basis for its popularity has been questioned. It is considered to be suitable for mild to moderate pain but not for more intense pain even in large doses. The World Health Organisation has devised a three-step analgesic ladder for the progressive treatment of increasing pain; on this codeine is considered a we...
متن کاملOpioid disposition in human sweat after controlled oral codeine administration.
BACKGROUND Characterization of opioid excretion in sweat is important for accurate interpretation of sweat tests in drug treatment, criminal justice, and workplace drug testing programs. METHODS Participants (n=20) received placebo, 3 low (60 mg/70 kg) or 3 high (120 mg/70 kg) codeine sulfate doses (used as a model for opioid excretion) within 1 week. Codeine and metabolites in sweat were col...
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ژورنال
عنوان ژورنال: Journal of Analytical Toxicology
سال: 2001
ISSN: 0146-4760,1945-2403
DOI: 10.1093/jat/25.6.486